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Central Nervous System Disorders with Auto-Antibodies in People Living with HIV.

Central Nervous System Disorders with Auto-Antibodies in People Living with HIV.

Authors :
Stroffolini, Giacomo
Atzori, Cristiana
Imperiale, Daniele
Trunfio, Mattia
Di Perri, Giovanni
Calcagno, Andrea
Source :
Microorganisms; Sep2024, Vol. 12 Issue 9, p1758, 10p
Publication Year :
2024

Abstract

Abstract: People living with HIV (PLWH) may present atypical neurological complications. Recently, autoimmune manifestations of the central nervous system (CNS) have been described. We retrospectively described the features of PLWH presenting with acute neurological symptoms with positive anti-CNS antibodies. We analyzed relevant CSF characteristics. Twelve patients were identified, with demyelinating, inflammatory, or no MRI lesions. We observed CSF inflammatory features. Aspecific CSF anti-CNS antibodies were found in all subjects and a specific antibody (second-level blotting panel) was found in one. The cases presented a slow resolution of symptoms with sequelae. More studies are needed to better describe the spectrum and prognosis of autoimmune CNS diseases in PLWH. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20762607
Volume :
12
Issue :
9
Database :
Complementary Index
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
180013299
Full Text :
https://doi.org/10.3390/microorganisms12091758