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Three in One with Dual-Functional Hydrogel of Lactoferrin/NZ2114/LMSH Promoting Staphylococcus aureus -Infected Wound Healing.

Authors :
Zhang, Kun
Ma, Xuanxuan
Teng, Da
Mao, Ruoyu
Yang, Na
Hao, Ya
Wang, Jianhua
Source :
Antibiotics (2079-6382); Sep2024, Vol. 13 Issue 9, p889, 17p
Publication Year :
2024

Abstract

Wound infections caused by Staphylococcus aureus often result in localized suppurative lesions that severely impede the healing process, so it is urgent to develop a dress with efficient antimicrobial and pro-healing functions. In this study, the bifunctional injectable hydrogel lactoferrin (Lf)/NZ2114/lithium magnesium silicate hydrogel (LMSH) was first successfully prepared through the electrostatic interaction method. The physical, biological, and efficacy properties are systematically analyzed with good shear-thinning capacity and biocompatibility. More importantly, it inhibits infection and promotes wound healing in a mouse wound infection model after 14 d treatment, and the bactericidal rate and healing rate were over 99.92% and nearly 100%, respectively. Meanwhile, the massive reduction of inflammatory cells, restoration of tissue structure, and angiogenesis in mice showed the anti-inflammatory and pro-healing properties of the hydrogel. The healed wounds showed thickening with more hair follicles and glands, suggesting that the hydrogel Lf/NZ2114/LMSH (Three in One) could be a better dressing candidate for the treatment of S. aureus-induced wound infections. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20796382
Volume :
13
Issue :
9
Database :
Complementary Index
Journal :
Antibiotics (2079-6382)
Publication Type :
Academic Journal
Accession number :
180012657
Full Text :
https://doi.org/10.3390/antibiotics13090889