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Anti-inflammatory Prowess of endothelial progenitor cells in the realm of biology and medicine.
- Source :
- NPJ Regenerative Medicine; 9/30/2024, Vol. 9 Issue 1, p1-15, 15p
- Publication Year :
- 2024
-
Abstract
- Endothelial inflammation plays a crucial role in vascular-related diseases, a leading cause of global mortality. Among various cellular players, endothelial progenitor cells (EPCs) emerge as non-differentiated endothelial cells circulating in the bloodstream. Recent evidence highlights the transformative role of EPCs in shifting from an inflammatory/immunosuppressive crisis to an anti-inflammatory/immunomodulatory response. Despite the importance of these functions, the regulatory mechanisms governing EPC activities and their physiological significance in vascular regenerative medicine remain elusive. Surprisingly, the current literature lacks a comprehensive review of EPCs' effects on inflammatory processes. This narrative review aims to fill this gap by exploring the cutting-edge role of EPCs against inflammation, from molecular intricacies to broader medical perspectives. By examining how EPCs modulate inflammatory responses, we aim to unravel their anti-inflammatory significance in vascular regenerative medicine, deepening insights into EPCs' molecular mechanisms and guiding future therapeutic strategies targeting vascular-related diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROGENITOR cells
ENDOTHELIAL cells
VASCULAR medicine
REGENERATIVE medicine
CYTOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 20573995
- Volume :
- 9
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- NPJ Regenerative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 180003525
- Full Text :
- https://doi.org/10.1038/s41536-024-00365-z