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INPIC-4F Nonfullerene Acceptor Nanoparticles for Fluorescence Imaging-Guided Photothermal and Photodynamic Cancer Therapy.
- Source :
- ACS Applied Nano Materials; 9/27/2024, Vol. 7 Issue 18, p21296-21303, 8p
- Publication Year :
- 2024
-
Abstract
- Phototheranostics, which consists of photothermal therapy (PTT) and photodynamic therapy (PDT), has exhibited huge potential in preventing the development of cancer. Then, phototheranostics utilizing photoacoustic imaging (PAI) in the second near-infrared (NIR-II) region, combined with high photothermal conversion efficiency (PCE) and cytotoxic reactive oxygen species (ROS) generation. In this work, we designed and prepared a fused-ring acceptor–donor–acceptor (A–D–A) molecule structure named INPIC-4F NP, known for its strong NIR light absorption and hydrophobic properties. INPIC-4F NPs in aqueous solution behaved excellently with NIR-II and PAI ability with NIR absorption at 808 nm and its fluorescence peaked at ∼1000 nm. With singlet oxygen in a quantum yield of 11%, INPIC-4F NPs showed potential for PDT ability. Moreover, INPIC-4F showed a PCE value of 83% under laser irradiation, which was obviously higher than that caused by photothermal agents, demonstrating an excellent PTT capacity. Combining previous and present results, INPIC-4F nanoparticles could improve the treatment effect for cancer through fluorescence imaging-guided photothermal and photodynamic synergistic therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 25740970
- Volume :
- 7
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- ACS Applied Nano Materials
- Publication Type :
- Academic Journal
- Accession number :
- 179998812
- Full Text :
- https://doi.org/10.1021/acsanm.4c02332