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Factors affecting discrepancies in disease activity evaluation between patients and physicians in systemic lupus erythematosus-The importance of symptoms such as fatigue.

Factors affecting discrepancies in disease activity evaluation between patients and physicians in systemic lupus erythematosus-The importance of symptoms such as fatigue.

Authors :
Doi, Hiroshi
Ohmura, Koichiro
Hashimoto, Motomu
Ueno, Kentaro
Takase, Yudai
Inaba, Ryuta
Kozuki, Tomohiro
Iwasaki, Takeshi
Taniguchi, Masashi
Tabuchi, Yuya
Shirakashi, Mirei
Onizawa, Hideo
Tsuji, Hideaki
Onishi, Akira
Watanabe, Ryu
Kitagori, Koji
Akizuki, Shuji
Murakami, Kosaku
Nakashima, Ran
Yoshifuji, Hajime
Source :
Lupus; Oct2024, Vol. 33 Issue 12, p1336-1344, 9p
Publication Year :
2024

Abstract

Objectives: There are often discrepancies in the evaluation of disease activity between patients and physicians in systemic lupus erythematosus (SLE). In this study, we examined the factors that affect those evaluations. Methods: Physician visual analogue scale (Ph-VAS), patient VAS (Pt-VAS), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2k), glucocorticoid (GC) usage and dose, age, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and three patient-reported outcomes (SLE symptom checklist [SSC], short-form 36 questionnaire [SF-36], and LupusPRO) were obtained from a study performed in 2019 using 225 SLE outpatients of the Kyoto Lupus Cohort at Kyoto University Hospital. Correlations among Ph-VAS, Pt-VAS, or dif (Pt-VAS-Ph-VAS) (Pt-VAS minus Ph-VAS) and other factors were examined. Results: We found a significant discrepancy between Pt-VAS (median 38.0 mm) and Ph-VAS (median 18.7 mm) scores (p < 0.001). SSC score showed a significant correlation with Pt-VAS and dif (Pt-VAS-Ph-VAS) (p < 0.001). Among SSC items, fatigue showed the most significant correlation with dif (Pt-VAS-Ph-VAS). We also showed that higher dif (Pt-VAS-Ph-VAS) was associated with lower quality of life (QOL) evaluated by SF-36 and LupusPRO. Conclusions: Pt-VAS scores tended to be higher than Ph-VAS scores, and the discrepancy was influenced mainly by fatigue. Higher dif (Pt-VAS-Ph-VAS) was associated with lower patient QOL. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09612033
Volume :
33
Issue :
12
Database :
Complementary Index
Journal :
Lupus
Publication Type :
Academic Journal
Accession number :
179974258
Full Text :
https://doi.org/10.1177/09612033241281909