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The role of cholesterol metabolism in lung cancer.

Authors :
XIU, WEIGANG
LIU, XINGYU
HU, KAIXIN
ZHANG, QIN
SHI, HUASHAN
Source :
Oncology Research; 12/20/2024, Vol. 32 Issue 10, p1613-1621, 9p
Publication Year :
2024

Abstract

Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the tumor microenvironment and within tumor cells significantly influence cell growth, proliferation, and metastasis. The effects of cholesterol metabolism are further mediated by the reprogramming of immune cells such as T cells, B cells, macrophages, myeloid-derived suppressor cells, among others. Ongoing research is investigating drugs targeting cholesterol metabolism for clinical treatments. Statins, targeting the cholesterol biosynthesis pathway, are widely employed in lung cancer treatment, either as standalone agents or in combination with other drugs. Additionally, drugs focusing on cholesterol transportation have shown promise as effective therapies for lung cancer. In this review, we summarized current research regarding the rule of cholesterol metabolism and therapeutic advances in lung cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09650407
Volume :
32
Issue :
10
Database :
Complementary Index
Journal :
Oncology Research
Publication Type :
Academic Journal
Accession number :
179953669
Full Text :
https://doi.org/10.32604/or.2024.047933