National Institutes of Health Researchers Describe Findings in Allotransplantation (Galectin-1 is associated with hematopoietic cell engraftment in murine MHC-mismatched allotransplantation).

A recent study conducted by researchers at the National Institutes of Health explores the role of Galectin-1 (Gal-1) in hematopoietic cell engraftment in murine MHC-mismatched allotransplantation. The study focuses on haploidentical hematopoietic cell transplantation (haplo-HCT) and its association with an increased risk of allograft rejection. The researchers found that Gal-1 may favor hematopoietic stem cell (HSC) engraftment in the murine model, and Gal-1-expressing regulatory T cells (Tregs) are associated with inducing immune tolerance and stable mixed chimerism after HCT. This research provides valuable insights into the mechanisms of allotransplantation and may have implications for improving transplant outcomes. [Extracted from the article]