Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network.

A preprint abstract from biorxiv.org discusses the role of the p53 gene in tumor suppression. The study used various techniques, including genome editing and CRISPR/Cas9 screens, to investigate the specific target genes of p53 that are important for tumor suppression. The researchers identified Zmat3 and Cdkn1a as key genes involved in p53-mediated tumor suppression, and found that their inactivation led to increased cell proliferation and migration. These findings suggest that Zmat3 and Cdkn1a play a crucial role in opposing tumorigenesis in different cellular and genetic contexts. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]