Patent Issued for Therapeutic alteration of transplantable tissues through In Situ or Ex Vivo exposure to RNA interference molecules (USPTO 12084660).

A patent has been issued to the University of Massachusetts for a method of therapeutic alteration of transplantable tissues using RNA interference molecules. The invention aims to minimize organ rejection, transmission of viral infections during transplantation, and apoptosis in transplanted tissues. The RNA interference molecules can be delivered to transplantable tissues through various methods, such as perfusion or injection. The patent also includes methods for treating organs at risk of apoptosis-induced ischemic injury. The invention has potential applications in treating various organs, including the kidney, liver, pancreas, heart, and lung. [Extracted from the article]