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Skeletal muscle hypertrophy: cell growth is cell growth.

Authors :
Burke, Benjamin I.
Ismaeel, Ahmed
Walden, Ferdinand von
Murach, Kevin A.
McCarthy, John J.
Source :
American Journal of Physiology: Cell Physiology; Sep2024, Vol. 327 Issue 3, pC614-C618, 5p
Publication Year :
2024

Abstract

Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the robustness of the model overshadows surgical limitations. We also compare the transcriptomic responses to synergist ablation in mice and resistance exercise in humans to identify common pathways. We conclude that "cell growth is cell growth" and that the mechanisms available to cells to accumulate biomass and increase in size are similar across cell types and independent of the rate of growth. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03636143
Volume :
327
Issue :
3
Database :
Complementary Index
Journal :
American Journal of Physiology: Cell Physiology
Publication Type :
Academic Journal
Accession number :
179874927
Full Text :
https://doi.org/10.1152/ajpcell.00418.2024