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Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis.

Authors :
Li, Dayan J.
Berry, Charlotte E.
Wan, Derrick C.
Longaker, Michael T.
Source :
Science Translational Medicine; 9/25/2024, Vol. 16 Issue 766, p1-17, 17p
Publication Year :
2024

Abstract

When dysregulated, skin fibrosis can lead to a multitude of pathologies. We provide a framework for understanding the wide clinical spectrum, mechanisms, and management of cutaneous fibrosis encompassing a variety of matrix disorders, fibrohistiocytic neoplasms, injury-induced scarring, and autoimmune scleroses. Underlying such entities are common mechanistic pathways that leverage morphogenic signaling, immune activation, and mechanotransduction to modulate fibroblast function. In light of the limited array of available treatments for cutaneous fibrosis, scientific insights have opened new therapeutic and investigative avenues for conditions that still lack effective interventions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19466234
Volume :
16
Issue :
766
Database :
Complementary Index
Journal :
Science Translational Medicine
Publication Type :
Academic Journal
Accession number :
179869847
Full Text :
https://doi.org/10.1126/scitranslmed.adn7871