Back to Search Start Over

The role of OX40 ligand/OX40 axis signalling in atopic dermatitis.

Authors :
Guttman-Yassky, Emma
Croft, Michael
Geng, Bob
Rynkiewicz, Natalie
Lucchesi, Davide
Peakman, Mark
Krinks, Cassandra van
Valdecantos, Wendell
Xing, Heming
Weidinger, Stephan
Source :
British Journal of Dermatology; Oct2024, Vol. 191 Issue 4, p488-496, 9p
Publication Year :
2024

Abstract

Atopic dermatitis (AD) is a heterogeneous inflammatory condition involving multiple immune pathways mediated by pathogenic T cells. OX40 ligand (OX40L) and OX40 are costimulatory immune checkpoint molecules that regulate effector and memory T-cell activity and promote sustained immune responses in multiple immunological pathways, including T helper (Th)2, Th1, Th17 and Th22. As such, OX40L/OX40 signalling between antigen-presenting cells (APCs) and activated T cells postantigen recognition promotes pathogenic T-cell proliferation and survival. Under inflammatory conditions, OX40L is upregulated on APCs, enhancing the magnitude of antigen-specific T-cell responses and secretion of proinflammatory cytokines. In AD, OX40L/OX40 signalling contributes to the amplification and chronic persistence of T-cell-mediated inflammation. Recent therapeutic success in clinical trials has highlighted the importance of the OX40L/OX40 axis as a promising target for the treatment of AD. Here, we discuss the many factors that are involved in the expression of OX40L and OX40, including the cytokine milieu, antigen presentation, the inflammatory environment in AD, and the therapeutic direction influenced by this costimulatory pathway. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00070963
Volume :
191
Issue :
4
Database :
Complementary Index
Journal :
British Journal of Dermatology
Publication Type :
Academic Journal
Accession number :
179773418
Full Text :
https://doi.org/10.1093/bjd/ljae230