Emory University School of Medicine Researchers Detail Research in Candida albicans (Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans).

Researchers from Emory University School of Medicine have conducted a study on Candida albicans, an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised patients. The study focused on the impact of sinefungin, a natural nucleoside analog of S-adenosyl methionine, on the virulence of C. albicans. The researchers found that sinefungin impairs various pathogenic traits of C. albicans, including hyphal morphogenesis, biofilm formation, adhesion to epithelial cells, and virulence towards Galleria mellonella. The study suggests that sinefungin could be a potential avenue for therapeutic intervention against C. albicans. Further exploration of post-transcriptional control mechanisms of pathogenicity is recommended for antifungal design. [Extracted from the article]