Researchers from Hebei Medical University Publish Research in Science and Technology (Lipid emulsion attenuates vasodilation by decreasing intracellular calcium and nitric oxide in vascular endothelial cells).

A recent study conducted by researchers from Hebei Medical University aimed to understand the mechanisms by which lipid emulsion (LE) reverses vasodilation in blood vessels. The study found that LE significantly attenuated acetylcholine-induced vasodilation in rat thoracic aortic rings and suppressed ATP-induced calcium elevation in human aortic endothelial cells. Additionally, LE pre-exposure reduced intracellular calcium concentration and suppressed nitric oxide (NO) synthesis, a key vasodilatory agent. These findings suggest that the reversal of vasodilation by LE may involve enhanced endoplasmic reticulum calcium uptake, leading to a reduction in intracellular calcium concentration and suppression of NO synthesis. [Extracted from the article]