Findings from University of Wisconsin - Milwaukee in the Area of Alzheimer Disease Described (apoe4-related Differences In Cortical Thickness Are Modulated By Sex In Middle Age).

A new report from the University of Wisconsin - Milwaukee explores the relationship between sex, APOE status, and cortical thickness in middle-aged adults. The study found that females had thicker superior frontal cortices and other brain regions compared to males. Additionally, APOE4-related differences in cortical thickness were more pronounced in females and detectable in middle age, well before the onset of clinical symptoms of Alzheimer's disease. This research provides valuable insights into the genetic and sex-related factors that may contribute to the development of Alzheimer's disease. [Extracted from the article]