Patent Issued for Alpha polyglutamated antifolates and uses thereof (USPTO 12076402).

L.E.A.F. Holdings Group LLC has been granted a patent for alpha polyglutamated antifolates, which can be used to treat diseases like cancer, immune system disorders, and infectious diseases. The patent explains how these antifolates can be delivered directly into cells in a higher-level polyglutamate form, bypassing the need for the cells to convert them. This method aims to address the limitations and resistance often associated with antifolate therapy. The patent also includes claims for a liposomal composition that contains the alpha polyglutamated antifolate, providing detailed information about its composition and potential applications in cancer treatment. [Extracted from the article]