Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024).

A recent article in Angewandte Chemie discusses a new method for monitoring vesicle dynamics using a synapse-mimicking nanopipette. The researchers developed a modified lipid layer within the nanopipette to mimic the lipid environment in synapses. By recording characteristic ionic current oscillations, they were able to evaluate the binding affinity of tau protein and found that phosphorylated tau inhibits vesicle dynamics through strong interactions with synaptic vesicles. This research provides valuable insights into the role of tau protein in synaptic function. [Extracted from the article]