Back to Search
Start Over
Predictive potential of dynamic contrast-enhanced MRI and plasma-derived angiogenic factors for response to concurrent chemoradiotherapy in human papillomavirus-negative oropharyngeal cancer.
- Source :
- Radiology & Oncology; Sep2024, Vol. 58 Issue 3, p366-375, 10p
- Publication Year :
- 2024
-
Abstract
- Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can assess tumour vascularity, which depends on the process of angiogenesis and affects tumour response to treatment. Our study explored the associations between DCE-MRI parameters and the expression of plasma angiogenic factors in human papilloma virus (HPV)-negative oropharyngeal cancer, as well as their predictive value for response to concurrent chemoradiotherapy (cCRT). Twenty-five patients with locally advanced HPV-negative oropharyngeal carcinoma were prospectively enrolled in the study. DCE-MRI and blood plasma sampling were conducted before cCRT, after receiving a radiation dose of 20 Gy, and after the completion of cCRT. Perfusion parameters k<subscript>trans</subscript>, k<subscript>ep</subscript>, V<subscript>e</subscript>, initial area under the curve (iAUC) and plasma expression levels of angiogenic factors (vascular endothelial growth factor [VEGF], connective tissue growth factor [CTGF], platelet-derived growth factor [PDGF]-AB, angiogenin [ANG], endostatin [END] and thrombospondin-1 [THBS1]) were measured at each time-point. Patients were stratified into responders and non-responders based on clinical evaluation. Differences and correlations between measures were used to generate prognostic models for response prediction. Higher perfusion parameter k<subscript>trans</subscript> and higher plasma VEGF levels successfully discriminated responders from non-responders across all measured time-points, whereas higher iAUC and higher plasma PDGF-AB levels were also discriminative at selected time points. Using early intra-treatment measurements of k<subscript>trans</subscript> and VEGF, a predictive model was created with cut-off values of 0.259 min<superscript>−1</superscript> for k<subscript>trans</subscript> and 62.5 pg/mL for plasma VEGF. Early intra-treatment DCE-MRI parameter k<subscript>trans</subscript> and plasma VEGF levels may be valuable early predictors of response to cCRT in HPV-negative oropharyngeal cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREDICTIVE tests
SQUAMOUS cell carcinoma
VASCULAR endothelial growth factors
RESEARCH funding
T-test (Statistics)
DATA analysis
OROPHARYNGEAL cancer
HEAD & neck cancer
CHEMORADIOTHERAPY
MAGNETIC resonance imaging
DESCRIPTIVE statistics
MANN Whitney U Test
LONGITUDINAL method
GROWTH factors
STATISTICS
DATA analysis software
CONFIDENCE intervals
PATHOLOGIC neovascularization
CONTRAST media
CONNECTIVE tissue growth factor
Subjects
Details
- Language :
- English
- ISSN :
- 13182099
- Volume :
- 58
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Radiology & Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 179695443
- Full Text :
- https://doi.org/10.2478/raon-2024-0044