Back to Search
Start Over
Geometric constraints regulated regioselectivity: Pd-catalyzed α-deuteration of pyridines with secondary phosphine oxide.
- Source :
- Chemical Communications; 9/25/2024, Vol. 60 Issue 75, p10338-10341, 4p
- Publication Year :
- 2024
-
Abstract
- A Pd-catalyzed regioselective H/D exchange at the α-position of pyridines was achieved by employing secondary phosphine oxide as an internal base. The proposed five-membered structure enabled the reaction to overcome its conventional ortho-directing feature, allowing the efficient deuteration of pyridines and quinolines at adjacent sites of N-atoms. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEUTERATION
QUINOLINE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 75
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 179664695
- Full Text :
- https://doi.org/10.1039/d4cc03089c