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Functions and Clinical Applications of Extracellular Vesicles in T H 2 Cell-Mediated Airway Inflammatory Diseases: A Review.

Functions and Clinical Applications of Extracellular Vesicles in T H 2 Cell-Mediated Airway Inflammatory Diseases: A Review.

Authors :
Cheon, Jaehwan
Kim, Byoungjae
Lee, Juhyun
Shin, Jaemin
Kim, Tae Hoon
Source :
International Journal of Molecular Sciences; Sep2024, Vol. 25 Issue 17, p9455, 20p
Publication Year :
2024

Abstract

Type 2 airway inflammation (T2AI), driven by type 2 innate lymphoid and CD4<superscript>+</superscript> T helper 2 cells, leads to various diseases and conditions, such as chronic rhinosinusitis with nasal polyps, allergic rhinitis, and asthma. Emerging evidence suggests the involvement of extracellular vesicles (EVs) in these diseases. In this review, we describe the immunological T2AI pathogenic mechanisms, outline EV characteristics, and highlight their applications in the diagnosis and treatment of T2AI. An extensive literature search was conducted using appropriate strategies to identify relevant articles from various online databases. EVs in various biological samples showed disease-specific characteristics for chronic rhinosinusitis with nasal polyps, allergic rhinitis, and asthma, with some demonstrating therapeutic effects against these conditions. However, most studies have been limited to in vitro and animal models, highlighting the need for further clinical research on the diagnostic and therapeutic applications of EVs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
25
Issue :
17
Database :
Complementary Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
179644532
Full Text :
https://doi.org/10.3390/ijms25179455