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Manganese boosts natural killer cell function via cGAS–STING mediated UTX expression.
- Source :
- MedComm; Sep2024, Vol. 5 Issue 9, p1-16, 16p
- Publication Year :
- 2024
-
Abstract
- Natural killer (NK) cells play a crucial role in both innate immunity and the activation of adaptive immunity. The activating effect of Mn2+ on cyclic GMP‐AMP(cGAS)–stimulator of interferon genes (STING signaling has been well known, but its effect on NK cells remains elusive. In this study, we identified the vital role of manganese (Mn2+) in NK cell activation. Mn2+ directly boosts cytotoxicity of NK cells and promotes the cytokine secretion by NK cells, thereby activating CD8+ T cells and enhancing their antitumor activity. Furthermore, Mn2+ can simultaneously activate NK‐cell intrinsic cGAS and STING and consequently augment the expression of ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX to promote the responsiveness of NK cells. Our results contribute to a broader comprehension of how cGAS–STING regulates NK cells. As a potent agonist of cGAS–STING, Mn2+ provides a promising option for NK cell‐based immunotherapy of cancers. [ABSTRACT FROM AUTHOR]
- Subjects :
- KILLER cells
CELL physiology
X chromosome
MANGANESE
T cells
Subjects
Details
- Language :
- English
- ISSN :
- 26882663
- Volume :
- 5
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- MedComm
- Publication Type :
- Academic Journal
- Accession number :
- 179639609
- Full Text :
- https://doi.org/10.1002/mco2.683