EVALUATION OF THYROID HORMONES AND ITS CORRELATION WITH RENAL FUNCTIONS IN UNDIALYZED CHRONIC KIDNEY DISEASE PATIENTS.

Background: To study the correlation of thyroid hormone profile with biochemical markers of renal function in patients with undialyzed chronic kidney disease. A lot of data is available for dialysis patients but only a few studies on undialyzed patients in our country. Method- A cross sectional study was done at Rajindra Hospital, Patiala on 100 undialyzed CKD patients above 18 years of age and excluded patients with existing thyroid disorder, taking drugs affecting thyroid function, pregnant females and previous history of dialysis. Renal functions and thyroid hormone levels were analysed and correlated. Result- Major proportion of the patients was in CKD stage 5 (53%). Mean age of the patients was 59.21±14.23 years. Mean FT3 levels were 2.92 ± 1.28, FT4 levels were 10.06 ± 7.51, and TSH values were 3.60 ± 3.28. In present study, 38% patients had euthyroidism, 13% had overt hypothyroidism, 38% had sick euthyroidism, and 11% had subclinical hypothyroidism. Out of those in CKD 5, 41.5% had sick euthyroidism followed by euthyroidism (34%), overt hypothyroidism (15.1%), and subclinical hypothyroidism (9.4%). Conclusion-. There is direct proportionate relationship between the incidence of low T3, T4 syndrome and increasing severity of the kidney disease. No correlation was found between the serum levels of T3 and T4 and the severity of CRF. Our data supports that renal disease leads to significant changes in thyroid hormone levels that unlocks the significance of thyroid hormone quantification in CKD patients. [ABSTRACT FROM AUTHOR]