A study of thyroid function abnormalities in patients with chronic kidney disease.

Aims and objectives: A study was conducted at Department of General Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, India, to see prevalence of thyroid disorder in CKD patients. Material and methods: An Observational Cross-Sectional Study was conducted at Department of General Medicine, Mahatma Gandhi Medical College and Hospital form August 2022 to October 2023. Patients who were on conservative management fulfilling the criteria for chronic kidney disease admitted in Department of Medicine, Mahatma Gandhi Hospital, Jaipur Results: Euthyroid was present in 63% patients, Primary hypothyroidism was present in 11% patients and Subclinical hypothyroidism was present in 26% patients. CKD stage IV showed higher mean T3 value (0.94) as compared to CKD stage V (0.608). CKD stage V showed higher mean TSH value (6.69) as compared to CKD stage IV (4.21). CKD stage IV showed higher mean GFR value (18.17) as compared to CKD stage V (8.16). Mean eGFR value of euthyroid (9.76) was significantly higher than subclinical hypothyroidism (7.11) and primary hypothyroidism (6.25) among eGFR level. Primary hypothyroidism was present 87.5% in CKD stage V patients and Subclinical hypothyroidism was present 84.2%% in CKD stage V patients. Conclusion: The mean TSH value was greater in CKD stage V (6.69) than in CKD stage IV (4.21). The mean GFR value for CKD stage IV was greater than that of CKD stage V (8.16), at 18.17. Therefore, it is crucial to check for thyroid disorders in all patients with chronic renal disease, since they may negatively impact the prognosis of the illness as a whole. [ABSTRACT FROM AUTHOR]