OC17.07: Quantitative cervicovaginal fluid fetal fibronectin: a liquid biopsy for intra‐amniotic inflammation.

This article discusses a study that aimed to determine whether a quantitative cervicovaginal fluid fetal fibronectin (fFN) test can be used to identify the presence of intra-amniotic inflammation in women with spontaneous preterm labor and intact membranes. The study included 78 patients who underwent transabdominal amniocentesis, and the diagnostic indices of the cervicovaginal fluid fFN test were calculated. The results showed that a cervicovaginal fluid fFN concentration of ≥125 ng/mL had high sensitivity, specificity, and positive likelihood ratio for identifying intra-amniotic inflammation. The authors conclude that this test can serve as a non-invasive liquid biopsy for intra-amniotic inflammation. [Extracted from the article]