Sex-Dependent Synaptic Alterations in a Mouse Model of Alzheimer’s Disease.

A recent study published in the Journal of Neuroscience examined sex-dependent synaptic alterations in a mouse model of Alzheimer's disease (AD). The study found that female mice exhibited increased amyloid burden and fewer presynaptic connections to the subiculum, a region of the brain involved in memory formation. These findings suggest that reduced input to the subiculum may be an underlying mechanism in memory impairment that worsens throughout the progression of AD. The study also highlighted the importance of investigating sex differences in AD research and the potential impact of synaptic alterations on sleep disturbances in women with AD. [Extracted from the article]