New Kids on the Hypertension Block: Novel Agents With New Mechanisms of Action.

The article discusses the lack of new molecules for the treatment of hypertension over the past 30 years, with the exception of the combination drug valsartan/sacubitril. However, there are now several new agents that target novel blood pressure regulating mechanisms, including endothelin receptor antagonists, non-steroidal mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, small interfering ribonucleic acid to inhibit the production of angiotensinogen, and M natriuretic peptide. These new agents offer potential advancements in the treatment of hypertension and provide researchers with exciting options for further exploration in the field. [Extracted from the article]