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Unveiling the role of PSMA5 in glioma progression and prognosis.

Authors :
Liu, Wei
Jia, Bo
Wang, Zan
Li, Chengcai
Li, Nanding
Tang, Jie
Wang, Jiwei
Source :
Discover Oncology; 9/6/2024, Vol. 15 Issue 1, p1-13, 13p
Publication Year :
2024

Abstract

Glioma is the most aggressive intracranial malignancy and is associated with poor survival rates and limited quality of life, impairing neuropsychological function and cognitive competence in survivors. The Proteasome Subunit Alpha Type-5 (PSMA5) is a multicatalytic proteinase complex that has been linked with tumor progression but is rarely reported in glioma. This study investigates the expression pattern, prognostic characteristics, and potential biological functions of PSMA5 in glioma. PSMA5 was significantly overexpressed in 28 types of cancer when compared to normal tissue. Furthermore, elevated levels of PSMA5 were observed in patients with wild-type isocitrate dehydrogenase 1 and exhibited a positive correlation with tumor grade. It was also found to be a standalone predictor of outcomes in glioma patients. Additionally, inhibiting PSMA5-induced cell cycle arrest may provide a therapeutic option for glioma. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
27306011
Volume :
15
Issue :
1
Database :
Complementary Index
Journal :
Discover Oncology
Publication Type :
Academic Journal
Accession number :
179505986
Full Text :
https://doi.org/10.1007/s12672-024-01296-3