Studies from Churchill Hospital Add New Findings in the Area of Salmonella Vaccines (The use of controlled human infection models to identify correlates of protection for invasive Salmonella vaccines).

A recent study conducted at Churchill Hospital in Oxford, United Kingdom, has explored the use of controlled human infection models (CHIM) to advance the development of Salmonella vaccines. CHIM studies involve deliberately exposing healthy human volunteers to an infectious agent, allowing researchers to estimate vaccine efficacy, study disease pathogenesis, and assess vaccine immunogenicity in a controlled environment. The research focuses on identifying immunological correlates of protection (CoP) for invasive Salmonella pathogens, such as Salmonella enterica serovar Typhi (S. Typhi) and nontyphoidal Salmonella (iNTS), which cause significant mortality and morbidity in low- and middle-income countries. The findings contribute to our understanding of immune mechanisms associated with protection following vaccination against invasive Salmonella pathogens. [Extracted from the article]