Patent Issued for Methods and compositions for inhibiting detoxification response (USPTO 12065648).

A patent has been issued for methods and compositions for inhibiting detoxification response. The patent, filed by inventors J. Amaranath Govindan and Gary Ruvkun, and assigned to General Hospital Corporation, focuses on the discovery that germline mutations in translation components can induce detoxification and immune responses in somatic cells. The inventors identified genes and signaling pathways involved in this response, which could be targeted to attenuate the response. The patent also discusses the use of microorganisms or their components as inhibitors of the response. The methods and compositions described in the patent could be used to treat subjects with translation defects or improve the pharmacokinetics of drugs that induce such a response. [Extracted from the article]