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Integrins in cancer stem cells.
- Source :
- Frontiers in Cell & Developmental Biology; 2024, p01-16, 16p
- Publication Year :
- 2024
-
Abstract
- Integrins are a class of adhesion receptors on cell membranes, consisting of α and β subunits. By binding to the extracellular matrix, integrins activate intracellular signaling pathways, participating in every step of cancer initiation and progression. Tumor stem cells possess self-renewal and self-differentiation abilities, along with strong tumorigenic potential. In this review, we discussed the role of integrins in cancer, with a focus on their impact on tumor stem cells and tumor stemness. This will aid in targeting tumor stem cells as a therapeutic approach, leading to the exploration of novel cancer treatment strategies. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER stem cells
CELL receptors
INTEGRINS
EXTRACELLULAR matrix
STEM cells
Subjects
Details
- Language :
- English
- ISSN :
- 2296634X
- Database :
- Complementary Index
- Journal :
- Frontiers in Cell & Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 179442596
- Full Text :
- https://doi.org/10.3389/fcell.2024.1434378