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A brief overview of SARS-CoV-2 infection and its management strategies: a recent update.

Authors :
Das, Alakesh
Pathak, Surajit
Premkumar, Madhavi
Sarpparajan, Chitra Veena
Balaji, Esther Raichel
Duttaroy, Asim K.
Banerjee, Antara
Source :
Molecular & Cellular Biochemistry; Sep2024, Vol. 479 Issue 9, p2195-2215, 21p
Publication Year :
2024

Abstract

The COVID-19 pandemic has become a global health crisis, inflicting substantial morbidity and mortality worldwide. A diverse range of symptoms, including fever, cough, dyspnea, and fatigue, characterizes COVID-19. A cytokine surge can exacerbate the disease's severity. This phenomenon involves an increased immune response, marked by the excessive release of inflammatory cytokines like IL-6, IL-8, TNF-α, and IFNγ, leading to tissue damage and organ dysfunction. Efforts to reduce the cytokine surge and its associated complications have garnered significant attention. Standardized management protocols have incorporated treatment strategies, with corticosteroids, chloroquine, and intravenous immunoglobulin taking the forefront. The recent therapeutic intervention has also assisted in novel strategies like repurposing existing medications and the utilization of in vitro drug screening methods to choose effective molecules against viral infections. Beyond acute management, the significance of comprehensive post-COVID-19 management strategies, like remedial measures including nutritional guidance, multidisciplinary care, and follow-up, has become increasingly evident. As the understanding of COVID-19 pathogenesis deepens, it is becoming increasingly evident that a tailored approach to therapy is imperative. This review focuses on effective treatment measures aimed at mitigating COVID-19 severity and highlights the significance of comprehensive COVID-19 management strategies that show promise in the battle against COVID-19. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03008177
Volume :
479
Issue :
9
Database :
Complementary Index
Journal :
Molecular & Cellular Biochemistry
Publication Type :
Academic Journal
Accession number :
179414499
Full Text :
https://doi.org/10.1007/s11010-023-04848-3