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Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs.
- Source :
- Pharmaceutics; Aug2024, Vol. 16 Issue 8, p971, 17p
- Publication Year :
- 2024
-
Abstract
- In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic "inulinated" analog of the "pegylated" PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, and SEM analyses, was conducted to elucidate the core/shell architecture of the carriers and in vitro cyto- and hemo-compatibility were assayed. The entrapment and in vitro delivery of sorafenib tosylate (ST) were also studied. INU-PLA copolymers exhibit distinctive features: (1) Crew-cut aggregates are formed with coronas of 2–4 nm; (2) a threshold surface density of 1 INU/nm<superscript>2</superscript> triggers a configuration change; (3) INU surface density influences PLA core dynamics, with hydrophilic segment stretching affecting PLA distribution towards the interface. INU-PLA<subscript>2</subscript>NPs demonstrated an outstanding loading of ST and excellent biological profile, with effective internalization and ST delivery to HepG2 cells, yielding a comparable IC<subscript>50</subscript>. [ABSTRACT FROM AUTHOR]
- Subjects :
- SORAFENIB
COPOLYMERS
NANOCARRIERS
NANOPARTICLES
POLYETHYLENE glycol
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 16
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 179384701
- Full Text :
- https://doi.org/10.3390/pharmaceutics16080971