Back to Search
Start Over
Exploring Pediatric Vertebral, Sacral, and Pelvic Osteosarcomas through the NCDB: Demographics, Treatment Utilization, and Survival Outcomes.
- Source :
- Children; Aug2024, Vol. 11 Issue 8, p1025, 14p
- Publication Year :
- 2024
-
Abstract
- Background and Objectives: Retrieve data from the National Cancer Database (NCDB) to examine information on the epidemiological prevalence, treatment strategies, and survival outcomes of pediatric vertebral, sacral and pelvic osteosarcomas. Methods: We reviewed NCDB data from 2008 to 2018, concentrating on vertebral, sacral, and pelvic osteosarcomas in children 0 to 21 years. Our analysis involved logistic and Poisson regression, Kaplan-Meier survival estimates, and Cox proportional hazards models. Results: The study population included 207 patients. For vertebral osteosarcomas, 62.5% of patients were female, and 78.1% were white. Regional lymph node involvement predicted 80 times higher mortality hazard (p = 0.021). Distant metastasis predicted 25 times higher mortality hazard (p = 0.027). For sacral and pelvic osteosarcomas, 58.3% of patients were male, and 72% were white. Patients with residual tumor were 4 times more likely to have prolonged LOS (p = 0.031). No residual tumor (HR = 0.53, p = 0.03) and radiotherapy receipt (HR = 0.46, p = 0.034) were associated with lower mortality hazards. Distant metastasis predicted 3 times higher mortality hazard (p < 0.001). Hispanic ethnicity was linked to lower resection odds (OR = 0.342, p = 0.043), possibly due to language barriers affecting patient understanding and care decisions. Conclusions: In conclusion, our examination of NCDB offers a thorough exploration of demographics, treatment patterns, and results, highlighting the importance of personalized approaches to enhance patient outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- OSTEOSARCOMA
DATABASES
PELVIC tumors
LOGISTIC regression analysis
SOCIOECONOMIC factors
TREATMENT effectiveness
DESCRIPTIVE statistics
MULTIVARIATE analysis
DECISION making in clinical medicine
PATIENT-centered care
KAPLAN-Meier estimator
ODDS ratio
METASTASIS
RACE
HEALTH equity
LENGTH of stay in hospitals
OVERALL survival
PROPORTIONAL hazards models
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 11
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 179381892
- Full Text :
- https://doi.org/10.3390/children11081025