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Barium Chloride-Induced Cardiac Arrhythmia Mouse Model Exerts an Experimental Arrhythmia for Pharmacological Investigations.
- Source :
- Life (2075-1729); Aug2024, Vol. 14 Issue 8, p1047, 13p
- Publication Year :
- 2024
-
Abstract
- Aim: Cardiac arrhythmias are among the most important pathologies that cause sudden death. The exploration of new therapeutic options against arrhythmias with low undesirable effects is of paramount importance. Methods: However, the convenient and typical animal model for screening the potential lead compound becomes a very critical modality, particularly in anti-arrhythmia. In this study, mice were intraperitoneally (i.p.) injected with BaCl<subscript>2</subscript>, CaCl<subscript>2</subscript>, and adrenaline to induce arrhythmia, and simultaneously compared with BaCl<subscript>2</subscript>-induced rats. Results: Electrocardiogram (ECG) showed that the majority of mice repeatedly developed ventricular bigeminy, ventricular tachycardia (VT), and ventricular fibrillation (VF) after BaCl<subscript>2</subscript>-injection as seen in rats. The ECG of mice developed ventricular bigeminy and VT after CaCl<subscript>2</subscript> and AT after adrenaline i.p. injection. Additionally, acute cardiac arrhythmia after BaCl<subscript>2</subscript> i.p. injection could be reverted by drugs (lidocaine and amiodarone) administration. Additionally, the different routes of administration for various chemical-induced arrhythmia in both mice and rats were also retrieved from PubMed and summarized. Comparing this approach with previous studies after the literature review reveals that arrhythmia of BaCl<subscript>2</subscript>-induced i.p. mice is compatible with the induction of other routes. Conclusions: This study brings an alternative experimental model to investigate antiarrhythmic theories and provides a promising approach to discovering new interventions for acute arrhythmias. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20751729
- Volume :
- 14
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Life (2075-1729)
- Publication Type :
- Academic Journal
- Accession number :
- 179376431
- Full Text :
- https://doi.org/10.3390/life14081047