Findings from National Taiwan University of Science and Technology Update Understanding of Liposomes (Polyelectrolyte-coated Liposomes Microfluidically Assembled In One-step for Enhancing Cell Endocytosis and In-vivo Immune Responses).

Researchers from the National Taiwan University of Science and Technology have developed a method for enhancing the cellular uptake of liposomes, which are nanocarriers used in vaccines. They synthesized surface-charged liposomes using a one-step microfluidic method and found that these liposomes exhibited higher endocytosis efficiencies compared to uncoated liposomes or those coated with anionic polyelectrolytes. The researchers also observed that mice vaccinated with a mixture of liposomes and an anthrax vaccine showed faster and stronger immune responses compared to those vaccinated with the vaccine alone. This study suggests that quaternary chitosan-coated liposomes can act as both nano-carriers and vaccine adjuvants to enhance immune responses. [Extracted from the article]