Study Data from Southern Medical University Provide New Insights into Glioblastomas (Framework Nucleic Acid-based Nanoparticles Enhance Temozolomide Sensitivity In Glioblastoma).

The article focuses on enhancing temozolomide (TMZ) sensitivity in glioblastoma (GBM) through the use of framework nucleic acid-based nanoparticles. Topics include the development of these nanoparticles to encapsulate and protect siMGMT, strategies for improving blood-brain barrier penetration and tumor targeting, and the significant improvement in TMZ efficacy achieved by this approach.