Investigators from Tongji University Release New Data on Heart Attack (N-acetyl-l-cysteine-modified Macrophage Membrane-coated Vegf Sustained-release Nanoparticles for Treatment of Myocardial Infarction: a Biomimetic Nano-buffer for...).

A recent study conducted by investigators from Tongji University in Shanghai, China, explores the potential use of a biomimetic nano-buffer system for the treatment of myocardial infarction (MI), or heart attack. The system consists of nanoparticles coated with N-acetyl-L-cysteine (NAC)-modified macrophage membrane, which accumulate at the infarcted myocardium and release vascular endothelial growth factor (VEGF) to promote angiogenesis. The nano-buffer system also scavenges reactive oxygen species and triggers the secretion of platelet-derived growth factor (PDGF) by macrophages, enhancing the maturation of blood vessels. The study highlights the potential of this nano-buffer system in treating MI. [Extracted from the article]