New Findings from Urmia University in the Area of Varicocele Described (Experimental Varicocele Impairs Dna Methylation and Demethylation In Germ Cells, Tese, and Epididymal Spermatozoa, Impacting Active Dna Demethylation In Zygotes).

A study conducted by researchers at Urmia University in Iran has found that varicocele, a condition that causes infertility, can impair DNA methylation and demethylation in germ cells, testicular sperm extraction (TESE)-derived spermatozoa, and epididymal spermatozoa. The study compared the impact of varicocele on DNA demethylation between TESE-derived and epididymal spermatozoa. The results showed that varicocele led to decreased expression levels of DNA methyltransferase 1 (DNMT1) and ten-eleven-translocation proteins (TET1, 2, 3) in testicles and spermatozoa, as well as lower DNA methylation and impaired embryo development. The study suggests that varicocele can negatively affect spermatogenesis and fertilization, leading to decreased embryo development and increased susceptibility to DNA damage. [Extracted from the article]