Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms (Updated August 17, 2024).

A recent preprint abstract discusses the role of cyclic di-GMP (c-di-GMP) as an antitoxin in regulating bacterial genome stability and antibiotic persistence in biofilms. Biofilms are bacterial communities that can cause chronic and relapsing infections. The study found that the toxin HipH induces DNA double strand breaks and genome instability, while c-di-GMP acts as the antitoxin, controlling HipH expression and activity. This unique toxin-antitoxin system has implications for understanding biofilm infections and potential treatments. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]