DIAGNOSTIC AND THERAPEUTIC APPROACH TO A PATIENT WITH CLEIDOCRANIAL DYSPLASIA - DENTAL ASPECT.

Cleidocranial dysplasia (CCD) is a rare autosomal dominant congenital syndrome occurring in approximately one in every million individuals worldwide, primarily affecting bones undergoing intramembranous ossification. Individuals with CCD exhibit hypoplasia or aplasia of the clavicles, open fontanelles and shorter stature, along with various forms of dental abnormalities. The gene RUNX2 plays an essential role in odontoblast and osteoblast differentiation, regulating the expression of many genes associated with the development of hard dental tissues. CCD is this accompanied by characteristic dental abnormalities such as supernumerary teeth, delayed eruption and impaction of permanent teeth. Intrafamilial variations of skeletal and dental abnormalities are well-known. The aim of this study is to present a clinical case and provide a diagnostic approach as a guide for practicing dentists, thereby facilitating their future work with these patients. [ABSTRACT FROM AUTHOR]