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Interleukin‐6 and interferon‐alpha differentially regulate microglia function.
- Source :
- Neuropathology & Applied Neurobiology; Aug2024, Vol. 50 Issue 4, p1-6, 6p
- Publication Year :
- 2024
-
Abstract
- Previous reports have shown that IL‐6 and IFN‐⍺ induce distinct transcriptomic and morphological changes in microglia. Here, we demonstrate that IL‐6 increases tissue surveillance, migration and phagocytosis in primary murine microglia, whereas IFN‐⍺ inhibits these functions. Our results provide a crucial link between transcriptome and function. It holds the potential to serve as the foundation for future studies aimed at identifying therapeutic targets for cytokine‐mediated neuroinflammatory diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHAGOCYTOSIS
MICROGLIA
DRUG target
TRANSCRIPTOMES
Subjects
Details
- Language :
- English
- ISSN :
- 03051846
- Volume :
- 50
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Neuropathology & Applied Neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 179298728
- Full Text :
- https://doi.org/10.1111/nan.13003