Circular RNA LIPH promotes pancreatic cancer glycolysis and progression through sponge miR‐769‐3p and interaction with GOLM1.

This article explores the role of a circular RNA called circLIPH in the progression of pancreatic cancer. The study reveals that circLIPH is increased in pancreatic tumor tissue and is associated with tumor size and stage. It also demonstrates that circLIPH promotes the growth, migration, and invasion of pancreatic cancer cells. The researchers identify miR-769-3p as a target of circLIPH and show that circLIPH increases the expression of GOLM1, a gene involved in cancer progression. These findings suggest that circLIPH could potentially be used as a biomarker and therapeutic target for pancreatic cancer. The study further investigates the role of circLIPH in pancreatic cancer progression and finds that overexpression of miR-769-3p inhibits the growth, proliferation, migration, and invasion of pancreatic cancer cells. Conversely, treatment with a miR-769-3p inhibitor has the opposite effects. The target genes of miR-769-3p are enriched in the mTOR signaling pathway. Additionally, circLIPH is found to promote pancreatic cancer progression by enhancing glycolysis in cancer cells. In vivo experiments demonstrate that si-circLIPH effectively reduces circLIPH expression and suppresses tumor growth. These findings suggest that circLIPH may activate the miR-769-3p/GOLM1/PI3K/AKT/mTOR axis to promote pancreatic cancer progression. [Extracted from the article]