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Smccnet 2.0: a comprehensive tool for multi-omics network inference with shiny visualization.

Authors :
Liu, Weixuan
Vu, Thao
R. Konigsberg, Iain
A. Pratte, Katherine
Zhuang, Yonghua
Kechris, Katerina J.
Source :
BMC Bioinformatics; 8/24/2024, Vol. 25 Issue 1, p1-23, 23p
Publication Year :
2024

Abstract

Summary: Sparse multiple canonical correlation network analysis (SmCCNet) is a machine learning technique for integrating omics data along with a variable of interest (e.g., phenotype of complex disease), and reconstructing multi-omics networks that are specific to this variable. We present the second-generation SmCCNet (SmCCNet 2.0) that adeptly integrates single or multiple omics data types along with a quantitative or binary phenotype of interest. In addition, this new package offers a streamlined setup process that can be configured manually or automatically, ensuring a flexible and user-friendly experience. Availability: This package is available in both CRAN: https://cran.r-project.org/web/packages/SmCCNet/index.html and Github: https://github.com/KechrisLab/SmCCNet under the MIT license. The network visualization tool is available at https://smccnet.shinyapps.io/smccnetnetwork/. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712105
Volume :
25
Issue :
1
Database :
Complementary Index
Journal :
BMC Bioinformatics
Publication Type :
Academic Journal
Accession number :
179231194
Full Text :
https://doi.org/10.1186/s12859-024-05900-9