New Data from University of California Illuminate Research in Squamous Cell Carcinoma (Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma).

A recent study conducted at the University of California focused on squamous cell carcinoma (SCC), a type of cancer. The study found that a specific gene mutation called histone lysine methyltransferase 2D (KMT2D) is frequently found in head and neck SCC. The researchers discovered that KMT2D deficiency promotes the growth of SCC by increasing glycolysis, a metabolic process. Additionally, KMT2D loss affects the expression of genes involved in the Fanconi Anemia/BRCA pathway, which is important for DNA repair. The study suggests that combining a glycolysis inhibitor with certain drugs may be an effective treatment for SCC patients with KMT2D mutations. [Extracted from the article]