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Designing Cobalt(II) Complex for Chemoselective Synthesis of 2‐Aryl‐3‐Formyl Indoles from Amino Alcohols and Alcohols†.
- Source :
- Chemistry - A European Journal; Aug2024, Vol. 30 Issue 47, p1-6, 6p
- Publication Year :
- 2024
-
Abstract
- An air‐stable, inexpensive, and isolable cobalt(II) complex (C1) of N‐((1‐methyl‐1H‐imidazol‐2‐yl)methyl)‐2‐(phenylselanyl)ethan amine (L1) was synthesized and characterized. The complex was used to catalyze a one‐pot cascade reaction between 2‐(2‐aminophenyl)ethanols and benzyl alcohol derivatives. Interestingly, 2‐aryl‐3‐formylindole derivatives were formed instead of N‐alkylated or C‐3 alkylated indoles. A broad substrate scope can be activated using this protocol with only 5.0 mol % catalyst loading to achieve up to 87 % yield of 2‐aryl‐3‐formylindole derivatives. The mechanistic studies suggested that the reaction proceeds through tandem imine formation followed by cyclization. [ABSTRACT FROM AUTHOR]
- Subjects :
- BENZYL alcohol
AMINO alcohols
BIOCHEMICAL substrates
INDOLE compounds
COBALT
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 30
- Issue :
- 47
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 179169441
- Full Text :
- https://doi.org/10.1002/chem.202401698