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A tensegrity-based mechanochemical model for capturing cell oscillation and reorientation.
- Source :
- Journal of Applied Physics; 8/21/2024, Vol. 136 Issue 7, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- The cytoskeleton, a dynamic network of structural proteins within cells, is essential for cellular deformation and responds to external mechanical cues. Here, based on the structure of the cytoskeleton, combined with the biochemical reactions of the activator RhoA and the inhibitor F-actin, we develop a novel mechanochemical cytoskeleton model to investigate the mechanical behavior of cells. Interestingly, we find that active stress fibers exhibit diverse dynamical modes at specific inhibitor concentration thresholds. The existence of concentration differences and sustained mechanochemical feedback in activators and inhibitors trigger a global oscillation of isolated cells. In addition, under uniaxial and biaxial stretches, activators and inhibitors preferentially diffuse toward the more significantly deformed cytoskeletal elements, and their dynamic interactions regulate the cell to align with the main stretching direction. Our findings, consistent with many experimental results, provide fundamental insights into cytoskeletal remodeling and cellular mechanosensing mechanisms. [ABSTRACT FROM AUTHOR]
- Subjects :
- MECHANICAL models
CYTOSKELETON
F-actin
OSCILLATIONS
DEFORMATIONS (Mechanics)
Subjects
Details
- Language :
- English
- ISSN :
- 00218979
- Volume :
- 136
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Applied Physics
- Publication Type :
- Academic Journal
- Accession number :
- 179145343
- Full Text :
- https://doi.org/10.1063/5.0226910