Role of Transcription Factor Misregulation in Lung Cancer.

Lung cancer persists as a conspicuously global health burden, accounting for its status as a leading cause of death and finite treatment options. Around 2 million diagnoses and 1.8 million deaths are a result of this disease around the world. In recent years, there has been a growing recognition of the crucial role that transcription factors play in the progression of lung cancer. Within the context of this disease, aberrant expression and dysregulation of transcription factors can lead to the uncontrolled growth of cancer cells, angiogenesis (the formation of new blood vessels), metastasis, and avoidance of apoptosis (programmed cell death). This comprehensive review paper will identify and review a few critical transcription factors involved in lung cancer pathogenesis and discuss their roles in shaping the development of various lung cancer subtypes. [ABSTRACT FROM AUTHOR]