Asynchronous movement of sarcomeres in myocardium under living conditions: role of titin.

This article explores the movement of sarcomeres in the heart muscle and the role of the protein titin in this process. It challenges previous beliefs by showing that sarcomeres do not all move in synchrony during muscle contraction. The asynchrony is influenced by factors such as sarcomere length and calcium levels. The article suggests that this asynchrony may contribute to impaired heart function in conditions like dilated cardiomyopathy. Further research is needed to understand the link between sarcomere movement and heart disease. [Extracted from the article]