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Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19.

Authors :
Strunz, Benedikt
Maucourant, Christopher
Mehta, Adi
Wan, Hui
Du, Likun
Sun, Dan
Chen, Puran
Nordlander, Anna
Gao, Yu
Cornillet, Martin
Bister, Jonna
Kvedaraite, Egle
Christ, Wanda
Klingström, Jonas
Geanon, Daniel
Parke, Åsa
Ekwall-Larson, Anna
Rivino, Laura
MacAry, Paul A
Aleman, Soo
Source :
Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, pe318-e326, 9p
Publication Year :
2024

Abstract

Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
230
Issue :
2
Database :
Complementary Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
179042536
Full Text :
https://doi.org/10.1093/infdis/jiae036