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Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19.
- Source :
- Journal of Infectious Diseases; 8/15/2024, Vol. 230 Issue 2, pe318-e326, 9p
- Publication Year :
- 2024
-
Abstract
- Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
COVID-19 pandemic
TYPE I interferons
BACTERIAL diseases
VIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 230
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 179042536
- Full Text :
- https://doi.org/10.1093/infdis/jiae036