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New insight into the CNC-bZIP member, NFE2L3, in human diseases.

Authors :
Guanghui Xiong
Jie Li
Fuli Yao
Fang Yang
Yuancai Xiang
Source :
Frontiers in Cell & Developmental Biology; 2024, p01-17, 17p
Publication Year :
2024

Abstract

Nuclear factor erythroid 2 (NF-E2)-related factor 3 (NFE2L3), amember of the CNCbZIP subfamily and widely found in a variety of tissues, is an endoplasmic reticulum (ER) membrane-anchored transcription factor that can be released from the ER and moved into the nucleus to bind the promoter region to regulate a series of target genes involved in antioxidant, inflammatory responses, and cell cycle regulation in response to extracellular or intracellular stress. Recent research, particularly in the past 5 years, has shed light on NFE2L3's participation in diverse biological processes, including cell differentiation, inflammatory responses, lipid homeostasis, immune responses, and tumor growth. Notably, NFE2L3 has been identified as a key player in the development and prognosis of multiple cancers including colorectal cancer, thyroid cancer, breast cancer, hepatocellular carcinoma, gastric cancer, renal cancer, bladder cancer, esophageal squamous cell carcinoma, T cell lymphoblastic lymphoma, pancreatic cancer, and squamous cell carcinoma. Furthermore, research has linked NFE2L3 to other cancers such as lung adenocarcinoma, malignant pleural mesothelioma, ovarian cancer, glioblastoma multiforme, and laryngeal carcinoma, indicating its potential as a target for innovative cancer treatment approaches. Therefore, to gain a better understanding of the role of NFE2L3 in disease, this review offers insights into the discovery, structure, function, and recent advancements in the study of NFE2L3 to lay the groundwork for the development of NFE2L3-targeted cancer therapies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2296634X
Database :
Complementary Index
Journal :
Frontiers in Cell & Developmental Biology
Publication Type :
Academic Journal
Accession number :
179019597
Full Text :
https://doi.org/10.3389/fcell.2024.1430486